Journal article

Relationship of the Optical Coherence Tomography Signal to Underlying Retinal Histology in the Tree Shrew (Tupaia belangeri)

Carla J Abbott, Neville A McBrien, Ulrike Gruenert, Michael J Pianta

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2009

Abstract

PURPOSE: To interpret the retinal origin of the optical coherence tomography (OCT) signal by objectively (i.e., minimal investigator bias) aligning in vivo OCT longitudinal reflectivity profiles (LRPs) with corresponding vertical histologic sections. METHODS: The Zeiss StratusOCT system was used to obtain retinal B-scans in vivo in eyes from adult tree shrews. Subsequently, the retinas were fixed and embedded. Semithin vertical sections through the retina were obtained from the same locations as the LRPs. A statistical correlation procedure that accounted for axial tissue shrinkage determined the best relationship between features in the LRP and sublaminae boundaries in corresponding histolo..

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Grants

Awarded by Supported by National Health and Medical Research Council of Australia


Funding Acknowledgements

Supported by National Health and Medical Research Council of Australia Grant 454602 (NAM), a Retina Australia Grant (MJP), a Lions Vision Research Fellowship (UG), and an Ernst and Grace Matthaei Scholarship (CJA).