Journal article

Biomechanics of the Sclera in Myopia: Extracellular and Cellular Factors

Neville A McBrien, Andrew I Jobling, Alex Gentle

OPTOMETRY AND VISION SCIENCE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009

Abstract

PURPOSE: Excessive axial elongation of the eye is the principal structural cause of myopia. The increase in eye size results from active remodelling of the sclera, producing a weakened scleral matrix. The present study will detail the biomechanics of the sclera and highlight the matrix and cellular factors important in the control of eye size. METHODS: Scleral elasticity (load vs. tissue extension) and creep rate (tissue extension vs. time) have been measured postmortem in human eyes. Animal models of myopia have allowed the direct relevance of scleral biomechanics to be investigated during myopia development. Recently, data on tissue matrices incorporating scleral fibroblasts have highlight..

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University of Melbourne Researchers