Determinants of Retinal Microvascular Architecture in Normal Subjects
Alun D Hughes, Tien Y Wong, Nicholas Witt, Richard Evans, Simon A Mcg Thom, Barbara E Klein, Nish Chaturvedi, Ronald Klein
MICROCIRCULATION | WILEY | Published : 2009
BACKGROUND: Recent studies have shown that changes in the retinal microvasculature predict cardiovascular disease (CVD); however, little is known regarding influences on the retinal microvasculature in healthy people without overt cardiovascular or metabolic disease. METHODS: We used a semiautomated computerized technique to analyze digitized retinal photographs from a total of 167 healthy people (age range, 45-75 years; 83 female), without clinical CVD, diabetes, or hypertension, randomly sampled from the population-based Beaver Dam Eye Study. We assessed arteriolar and venular narrowing, arteriolar optimality deviation, and other quantitative aspects of the retinal microvasculature. RESULT..View full abstract
Awarded by National Institutes of Health
Awarded by NATIONAL EYE INSTITUTE
The study was supported by a grant from the Wellcome Trust. We are grateful to Stacy Meuer and Karl Jensen for their excellent technical assistance with the study. The Beaver Dam Eye Study was supported by a National Institutes of Health grant (EY06594 to Ronald Klein and Barbara Klein). Professors Chaturvedi, Hughes, and Thom acknowledge the support of the NIHR Biomedical Research Centre Scheme.