Journal article

Determinants of Retinal Microvascular Architecture in Normal Subjects

Alun D Hughes, Tien Y Wong, Nicholas Witt, Richard Evans, Simon A Mcg Thom, Barbara E Klein, Nish Chaturvedi, Ronald Klein

MICROCIRCULATION | WILEY | Published : 2009

Abstract

BACKGROUND: Recent studies have shown that changes in the retinal microvasculature predict cardiovascular disease (CVD); however, little is known regarding influences on the retinal microvasculature in healthy people without overt cardiovascular or metabolic disease. METHODS: We used a semiautomated computerized technique to analyze digitized retinal photographs from a total of 167 healthy people (age range, 45-75 years; 83 female), without clinical CVD, diabetes, or hypertension, randomly sampled from the population-based Beaver Dam Eye Study. We assessed arteriolar and venular narrowing, arteriolar optimality deviation, and other quantitative aspects of the retinal microvasculature. RESULT..

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Grants

Awarded by National Institutes of Health


Awarded by NATIONAL EYE INSTITUTE


Funding Acknowledgements

The study was supported by a grant from the Wellcome Trust. We are grateful to Stacy Meuer and Karl Jensen for their excellent technical assistance with the study. The Beaver Dam Eye Study was supported by a National Institutes of Health grant (EY06594 to Ronald Klein and Barbara Klein). Professors Chaturvedi, Hughes, and Thom acknowledge the support of the NIHR Biomedical Research Centre Scheme.