Detection of NPM1 exon 12 mutations and FLT3-internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia

Angela YC Tan; David A Westerman; Dennis A Carney; John F Seymour; Surender Juneja; Alexander Dobrovic

Journal article

Detection of NPM1 exon 12 mutations and FLT3-internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia

Angela YC Tan, David A Westerman, Dennis A Carney, John F Seymour, Surender Juneja, Alexander Dobrovic

JOURNAL OF HEMATOLOGY & ONCOLOGY | BMC | Published : 2008

DOI: 10.1186/1756-8722-1-10

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University of Melbourne Researchers

David Westerman Author Medicine - St Vincent's Hospital

Dennis Carney Author Medical Education

John Seymour Author Medicine - St Vincent's Hospital

Alexander Dobrovic Author Surgery - Austin Health

Grants

Funding Acknowledgements

This work was supported in part by a grant from Novartis Pharmaceuticals. Michelle McBean from the Diagnostic Molecular Pathology Lab, Peter MacCallum Cancer Centre extracted the DNA samples. Lee Ping Chew provided the clinical information. Prof. Bruno Falini kindly donated the antiNPM antibody (clone 376) for immunohistochemical analysis. We also thank Michael Krypuy and Chelsee Hewitt for critical reading of this manuscript.