Journal article

Effect of Birth Parameters on Retinal Vascular Caliber The Twins Eye Study in Tasmania

Cong Sun, Anne-Louise Ponsonby, Tien Y Wong, Shayne A Brown, Lisa S Kearns, Jenny Cochrane, Jane R MacKinnon, Jonathan B Ruddle, Alex W Hewitt, Gerald Liew, Terence Dwyer, Katrina Scurrah, David A Mackey



Recent studies reported an association between smaller birth size and narrower retinal vascular caliber, but it remains unclear whether this association is attributed to confounding by shared environment or genetic factors. At a mean age of 9.3 years, 266 twins (49 monozygotic and 84 dizygotic pairs) in the Twins Eye Study in Tasmania underwent an ophthalmic examination including retinal photography. Retinal vascular caliber was measured using a validated protocol. The majority of these twins were also in the Tasmanian Infant Health Study, which prospectively collected data on birth parameters and antenatal maternal factors. We conducted the main analysis using linear mixed models, accountin..

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Awarded by Canberra Australia

Funding Acknowledgements

The research reported in this article was supported by Ophthalmic Research Institute of Australia, Foundation for Children Australia, National Health and Medical Research Council, Canberra Australia (project grant 350415), and the Clifford Craig Medical Research Trust. C.S. is the recipient of a National Health and Medical Research Council postgraduate scholarship. D.A.M. is the recipient of the Pfizer Australia Senior Research Fellowship.