Journal article

Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The multi-ethnic study of atherosclerosis (MESA)

Andreas J Kreis, Tien Yin Wong, FM Amirul Islam, Ronald Klein, Barbara EK Klein, Mary Frances Cotch, Alicia J Jenkins, Steven Shea, Jie Jin Wang

DIABETES & VASCULAR DISEASE RESEARCH | SAGE PUBLICATIONS LTD | Published : 2009

Abstract

OBJECTIVE: To examine the associations between nuclear magnetic resonance (NMR) defined lipoproteins and diabetic retinopathy (DR) in a population-based sample of adults with type 2 diabetes. RESEARCH DESIGN AND METHODS: In all, 921 persons with diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA) were included. DR was assessed from retinal photographs. Lipoproteins were measured by NMR spectroscopy. RESULTS: After controlling for age, race/ethnicity, study centre and diabetes and vascular risk factors, no consistent patterns of associations between NMR-defined lipoprotein particle concentrations and subclass with DR were evident. CONCLUSION: The lack of association between NMR-defin..

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Grants

Awarded by National Heart, Lung, and Blood Institute


Awarded by NIH


Awarded by National Eye Institute


Awarded by DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS


Awarded by NATIONAL EYE INSTITUTE


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

This research was supported by contracts N01-HC-95159 to N01-HC-95165 and N01-HC-95169 from the National Heart, Lung, and Blood Institute. Additional support was provided by NIH grant HL69979-03 (Klein R and Wong TY) and an intramural research programme award Z01EY000403 from the National Eye Institute, National Institutes of Health.