Sodium bicarbonate to prevent increases in serum creatinine after cardiac surgery: A pilot double-blind, randomized controlled trial

Abstract

OBJECTIVE:: To test whether perioperative sodium bicarbonate infusion can attenuate postoperative increases in serum creatinine in cardiac surgical patients. DESIGN:: Double-blind, randomized controlled trial. SETTING:: Operating rooms and intensive care unit at a tertiary hospital. PATIENTS:: Cohort of 100 cardiac surgical patients at increased risk of postoperative acute renal dysfunction. INTERVENTION:: Patients were randomized to either 24 hrs of intravenous infusion of sodium bicarbonate (4 mmol/kg) or sodium chloride (4 mmol/kg). MEASUREMENTS AND MAIN RESULTS:: The primary outcome measure was the proportion of patients developing acute renal dysfunction defined as a postoperative incre..