Sodium bicarbonate to prevent increases in serum creatinine after cardiac surgery: A pilot double-blind, randomized controlled trial
Michael Haase, Anja Haase-Fielitz, Rinaldo Bellomo, Prasad Devarajan, David Story, George Matalanis, Michael C Reade, Sean M Bagshaw, Narelle Seevanayagam, Siven Seevanayagam, Laurie Doolan, Brian Buxton, Duska Dragun
CRITICAL CARE MEDICINE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009
OBJECTIVE: To test whether perioperative sodium bicarbonate infusion can attenuate postoperative increases in serum creatinine in cardiac surgical patients. DESIGN: Double-blind, randomized controlled trial. SETTING: Operating rooms and intensive care unit at a tertiary hospital. PATIENTS: Cohort of 100 cardiac surgical patients at increased risk of postoperative acute renal dysfunction. INTERVENTION: Patients were randomized to either 24 hrs of intravenous infusion of sodium bicarbonate (4 mmol/kg) or sodium chloride (4 mmol/kg). MEASUREMENTS AND MAIN RESULTS: The primary outcome measure was the proportion of patients developing acute renal dysfunction defined as a postoperative increase in..View full abstract
This study was supported, in part, a grants from the Australian and New Zealand College of Anaesthetists and by the Austin Hospital Anesthesia and Intensive Care Trust Fund, both federal non-profit foundations.