Deterioration in cardiac systolic and diastolic function late in normal human pregnancy
Dominica Zentner, Moira du Plessis, Shaun Brennecke, James Wong, Leeanne Grigg, Stephen B Harrap
CLINICAL SCIENCE | PORTLAND PRESS LTD | Published : 2009
The aim of the present study was to undertake a longitudinal study of systolic and diastolic cardiac function during normal pregnancy. At a median of 16 weeks of gestation, 100 primiparous women underwent echocardiography, including tissue Doppler imaging, determining left ventricular mass, cardiac output, systolic and diastolic velocities, and wall stress. A total of 32 were assessed again at a median of 37 weeks of gestation. Non-pregnant control estimates (n=9) were obtained by averaging four separate measures over two menstrual cycles. Initially, the pregnant women had significantly higher pulse rates than controls, associated with greater ventricular wall stress (two-tailed P value=0.01..View full abstract
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Awarded by National Health and Medical Research Council Postgraduate Medical Scholarship
This work was supported by an Australian Postgraduate Award (to D.Z.); a National Health and Medical Research Council Postgraduate Medical Scholarship [scholarship number 359320 (to D.Z.)]; and by a Royal Melbourne Hospital Victor Hurley Research Fund Grant (to D.Z.).