Journal article

Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study)

Linda T Roten, Matthew P Johnson, Siri Forsmo, Elizabeth Fitzpatrick, Thomas D Dyer, Shaun P Brennecke, John Blangero, Eric K Moses, Rigmor Austgulen

EUROPEAN JOURNAL OF HUMAN GENETICS | NATURE PUBLISHING GROUP | Published : 2009

Abstract

Genome-wide scans in Icelandic, Australian/New Zealand and Finnish pedigrees have provided evidence for maternal susceptibility loci for pre-eclampsia on chromosome 2, although at different positions (Iceland: 2p13 and 2q23, Australia/New Zealand: 2p11-12 and 2q22, Finland: 2p25). In this project, a large population-based (n=65 000) nested case-control study was performed in Norway to further explore the association between positional candidate genes on chromosome 2q and pre-eclampsia, using single-nucleotide polymorphisms (SNPs). DNA samples from 1139 cases (women with one or more pre-eclamptic pregnancies) and 2269 controls (women with normal pregnancies) were genotyped using the Applied B..

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Grants

Awarded by National Institutes of Health


Awarded by National Center for Research Resources, NIH


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

The Nord-Trondelag Health Study (the HUNT study) is a collaboration between the HUNT Research Centre, Faculty of Medicine, NTNU, the Norwegian Institute of Public Health and the Nord-Trondelag County Council. We thank Drs Harald HH Goring and A sa Johansson for their constructive review of the manuscript. This study was supported by grants from the Central Norway Regional Health Authority and the Medical Faculty and Office of International Relations at NTNU (Linda T Roten), the Cowles Post-Doctoral Fellowship (Matthew P Johnson), the Elizabeth Huth Coates Charitable Foundation and grants from the National Institutes of Health. (Eric K Moses, R01HD049847; John Blangero, MH59490). Genotyping and statistical analysis were conducted in facilities constructed with support for the Research Facilities Improvement Program Grant Numbers C06 RR013556 and C06 RR017515 from the National Center for Research Resources, NIH.