Journal article

Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia

E Fitzpatrick, MP Johnson, TD Dyer, S Forrest, K Elliott, J Blangero, SP Brennecke, EK Moses

MOLECULAR HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2009

Abstract

Pre-eclampsia is a common serious disorder of human pregnancy, which is associated with significant maternal and perinatal morbidity and mortality. The suspected aetiology of pre-eclampsia is complex, with susceptibility being attributable to multiple environmental factors and a large genetic component. Recently, we reported significant linkage to chromosome 2q22 in 34 Australian/New Zealand (Aust/NZ) pre-eclampsia/eclampsia families, and activin A receptor type IIA (ACVR2A) was identified as a strong positional candidate gene at this locus. In an attempt to identify the putative risk variants, we have now comprehensively re-sequenced the entire coding region of the ACVR2A gene and the conse..

View full abstract

Grants

Awarded by National Institutes of Health, USA


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

This work was supported by the National Institutes of Health, USA [R01HD049847 to E. K. M., S. P. B. and J. B., MH059490 to J. B. and C06 RR017515]; and the San Antonio Area Foundation [Semp Russ Foundation to M. P. J.]. E. F. is the recipient of the Royal Women's Hospital Postgraduate Research Degree Scholarship. M. P. J. is the recipient of a Cowles Postdoctoral Fellowship.