Journal article
Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia
E Fitzpatrick, MP Johnson, TD Dyer, S Forrest, K Elliott, J Blangero, SP Brennecke, EK Moses
Molecular Human Reproduction | OXFORD UNIV PRESS | Published : 2009
Abstract
Pre-eclampsia is a common serious disorder of human pregnancy, which is associated with significant maternal and perinatal morbidity and mortality. The suspected aetiology of pre-eclampsia is complex, with susceptibility being attributable to multiple environmental factors and a large genetic component. Recently, we reported significant linkage to chromosome 2q22 in 34 Australian/New Zealand (Aust/NZ) pre-eclampsia/ eclampsia families, and activin A receptor type IIA (ACVR2A) was identified as a strong positional candidate gene at this locus. In an attempt to identify the putative risk variants, we have now comprehensively re-sequenced the entire coding region of the ACVR2A gene and the cons..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the National Institutes of Health, USA [R01HD049847 to E. K. M., S. P. B. and J. B., MH059490 to J. B. and C06 RR017515]; and the San Antonio Area Foundation [Semp Russ Foundation to M. P. J.]. E. F. is the recipient of the Royal Women's Hospital Postgraduate Research Degree Scholarship. M. P. J. is the recipient of a Cowles Postdoctoral Fellowship.