Cellular transfer of macromolecules across the developing choroid plexus of Monodelphis domestica
Shane A Liddelow, Katarzyna M Dziegielewska, C Joakim Ek, Pia A Johansson, Ann M Potter, Norman R Saunders
EUROPEAN JOURNAL OF NEUROSCIENCE | WILEY-BLACKWELL | Published : 2009
Choroid plexus epithelial cells secrete cerebrospinal fluid (CSF) and transfer molecules from blood into CSF. Tight junctions between choroidal epithelial cells are functionally effective from early in development: the route of transfer is suggested to be transcellular. Routes of transfer for endogenous and exogenous plasma proteins and dextrans were studied in Monodelphis domestica (opossum). Pups at postnatal (P) days 1-65 and young adults were injected with biotinylated dextrans (3-70 kDa) and/or foetal protein fetuin. CSF, plasma and brain samples were collected from terminally anaesthetized animals. Choroid plexus cells containing plasma proteins were detected immunocytochemically. Numb..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
This work was funded in part by the National Health and Medical Research Council (NHMRC) of Australia grant NHMRC 454399.