Journal article
Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of α6β1 integrin
M Colomiere, J Findlay, L Ackland, N Ahmed
International Journal of Biochemistry and Cell Biology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2009
Abstract
Peritoneal dissemination of ovarian carcinoma is mediated by epithelial-mesenchymal interconversions leading to the disruption of cell-cell contact and modulation of cell-extracellular matrix (ECM) interactions. The present study was designed to evaluate the effects of epidermal growth factor (EGF) as a modulator of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) signalling and changes in integrin expression during the process similar to EMT. A fibroblastic morphology with reduced intercellular cell contacts and increased cell motility was observed in ovarian cancer cell lines in response to EGF and was concomitant with the up regulation of EMT-associated..
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Funding Acknowledgements
The authors wish to thank Professor Michael Quinn, Royal Women's Hospital, Melbourne, Australia, for his help with the procurement of human tissues. We also thank Mr. Clyde Riley with his assistance with the immunohistochemistry. This work was supported by the Royal Women's Hospital Foundation, Melbourne, Australia.