Journal article

The outcome of non-typhoidal salmonella meningitis in Malawian children, 1997-2006

EM Molyneux, LA Mankhambo, Ajib Phiri, SM Graham, H Forsyth, Amos Phiri, AL Walsh, LK Wilson, ME Molyneux

ANNALS OF TROPICAL PAEDIATRICS | MANEY PUBLISHING | Published : 2009

Abstract

INTRODUCTION: The clinical course and outcome of non-typhoidal salmonella (NTS) meningitis in Malawian children over a 10-year period (1997-2006) is described. METHODS: Demographic, clinical and laboratory data were collected for all children over 2 months of age admitted with salmonella meningitis to Queen Elizabeth Central Hospital from 1997 to 2006. In the 1st year, salmonellae were susceptible to chloramphenicol, and children received 2 weeks of chloramphenicol treatment. When NTS resistance to chloramphenicol started to appear in 1998, treatment was changed to ceftriaxone. From 2002, the duration of antibiotic therapy was extended to 4-weeks which included 2 weeks of intravenous ceftria..

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