Journal article

Developmental and Neuropathological Consequences of Ductal Ligation in the Preterm Baboon

Michelle Loeliger, Terrie E Inder, Penelope A Dalitz, Sarah Cain, Emily J Camm, Bradley Yoder, Donald McCurnin, Phillip W Shaul, Ronald Clyman, Sandra M Rees

PEDIATRIC RESEARCH | INT PEDIATRIC RESEARCH FOUNDATION, INC | Published : 2009

Abstract

A patent ductus arteriosus (PDA) alters pulmonary mechanics and regional blood flow in the preterm infant. Its significance with respect to brain injury and brain development are unclear. We evaluated the effects of surgical ductal ligation on the preterm baboon brain. Baboons were delivered at 125 d of gestation (dg, term approximately 185 dg) and ventilated for 14 d (n = 12). The PDA was ligated 6 d after delivery (n = 7) or left untreated (n = 5). Animals were euthanized at 139 dg and brains compared histologically with gestational control fetuses (n = 7) at 140 dg. Brain and body weights were reduced (p < 0.05) in both groups of ventilated preterm animals; however, the brain to body weig..

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University of Melbourne Researchers