Dark adaptation recovery of human rod bipolar cell response kinetics estimated from scotopic b-wave measurements
AM Cameron, L Miao, R Ruseckaite, MJ Pianta, TD Lamb
JOURNAL OF PHYSIOLOGY-LONDON | WILEY | Published : 2008
We recorded ganzfeld scotopic ERGs to examine the responses of human rod bipolar cells in vivo, during dark adaptation recovery following bleaching exposures, as well as during adaptation to steady background lights. In order to be able to record responses at relatively early times in recovery, we utilized a 'criterion response amplitude' protocol in which the test flash strength was adjusted to elicit responses of nearly constant amplitude. In order to provide accurate and unbiased measures of response kinetics, we utilized a curve-fitting procedure to fit a smooth function to the measured responses in the vicinity of the peak, thereby extracting both the time-to-peak and the amplitude of t..View full abstract
Awarded by ARC Federation Fellowship
Awarded by ARC Centres of Excellence
We thank Liz Bowman, Elsbeth Wood, and Pei Yoong Lim for assistance with experiments. Supported by ARC Federation Fellowship FF0344672 and ARC Centres of Excellence grant CE0561903.