Journal article

A recombinant Sendai virus is controlled by CD4( ) effector T cells responding to a secreted human immunodeficiency virus type 1 envelope glycoprotein

Scott A Brown, Julia L Hurwitz, Amy Zirkel, Sherri Surman, Toru Takitnoto, Irina Alyrnova, Chris Coleclough, Allen Portner, Peter C Doherty, Karen S Slobod

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2007

Abstract

The importance of antigen-specific CD4(+) helper T cells in virus infections is well recognized, but their possible role as direct mediators of virus clearance is less well characterized. Here we describe a recombinant Sendai virus strategy for probing the effector role(s) of CD4(+) T cells. Mice were vaccinated with DNA and vaccinia virus recombinant vectors encoding a secreted human immunodeficiency virus type 1 (HIV-1) envelope protein and then challenged with a Sendai virus carrying a homologous HIV-1 envelope gene. The primed mice showed (i) prompt homing of numerous envelope-primed CD4(+) T cell populations to the virus-infected lung, (ii) substantial production of gamma interferon, an..

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University of Melbourne Researchers