The contribution of human cone photoreceptors to the photopic flicker electroretinogram
Richa Verma, Michael J Pianta
JOURNAL OF VISION | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2009
We aimed to noninvasively estimate the relative contribution of the cone photoreceptors to the photopic flicker electroretinogram (ERG) in humans. Responses to ganzfeld square-wave flicker (15, 30, and 60 Hz) were recorded in the presence of a rod-saturating background. We used a modified paired flash technique in which a bright probe flash was presented at different times during a flicker cycle and the ERG response was recorded. The cone photoreceptor response was estimated by comparing the relative amplitude of the response during a flicker cycle to the response in the absence of flicker, at early times after the presentation of the probe flash. The normalized responses were then scaled to..View full abstract
This work was supported by an Early Career Researcher Grant from the University of Melbourne to MJP. Preparation of the manuscript was supported by a David Hay Memorial Fund (Postgraduate Writing-Up Award) to RV. We are grateful to Prof. T. D. Lamb for insightful comments on an early version of the manuscript.