Journal article

The contribution of human cone photoreceptors to the photopic flicker electroretinogram

Richa Verma, Michael J Pianta

JOURNAL OF VISION | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2009

Abstract

We aimed to noninvasively estimate the relative contribution of the cone photoreceptors to the photopic flicker electroretinogram (ERG) in humans. Responses to ganzfeld square-wave flicker (15, 30, and 60 Hz) were recorded in the presence of a rod-saturating background. We used a modified paired flash technique in which a bright probe flash was presented at different times during a flicker cycle and the ERG response was recorded. The cone photoreceptor response was estimated by comparing the relative amplitude of the response during a flicker cycle to the response in the absence of flicker, at early times after the presentation of the probe flash. The normalized responses were then scaled to..

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Grants

Funding Acknowledgements

This work was supported by an Early Career Researcher Grant from the University of Melbourne to MJP. Preparation of the manuscript was supported by a David Hay Memorial Fund (Postgraduate Writing-Up Award) to RV. We are grateful to Prof. T. D. Lamb for insightful comments on an early version of the manuscript.