Journal article

Recent advances in postmortem pathology and neurochemistry in schizophrenia

Brian Dean, Simone Boer, Andrew Gibbons, Tammie Money, Elizabeth Scarr

CURRENT OPINION IN PSYCHIATRY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009

Abstract

PURPOSE OF REVIEW: This is a review examining recent data from the study of the postmortem central nervous system (CNS) of patients with schizophrenia. RECENT FINDINGS: Studies on the human CNS transcriptome suggest changes in pro-inflammatory pathways and myelination in schizophrenia, whereas changes in the proteome suggest that pathways involved in energy and metabolism may be particularly stressed. There appear to be complex changes in the expression of proposed candidate genes for schizophrenia such as NRG1, DISC1, RGS4 and DTNB1, and there are continued reports of alterations in central gamma-aminobutyric acidergic, dopaminergic, glutamatergic and cholinergic pathways in patients with t..

View full abstract

Grants

Awarded by NHMRC


Awarded by NIH


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

This work was funded in part by NHMRC Project Grants 192399 and 509333, NIH Grant R01 MH069696 and the Rebecca L. Cooper Medical Research Foundation. B.D. is a Senior NHMRC Research Fellow (Level B) (400016). E.S. is the Royce Abbey Postdoctoral Fellow (mental illness). T.M. currently holds an Australian Rotary Health Research Fund Ian Scott Scholarship.