Immune characterization of an individual with an exceptionally high natural killer T cell frequency and her immediate family
AC Chan, L Serwecinska, A Cochrane, LC Harrison, DI Godfrey, SP Berzins
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | WILEY | Published : 2009
Natural killer T cells (NKT) are a regulatory subset of T lymphocytes whose frequency in peripheral blood is highly variable within the human population. Lower than normal NKT frequencies are associated with increased predisposition to a number of diseases, including type 1 diabetes and some forms of cancer, raising the possibility that an increased frequency may be protective. However, there is little or no understanding of how high NKT frequencies arise or, most importantly, whether the potential exists to boost and maintain NKT levels for therapeutic advantage. Here, we provide a detailed functional and phenotypic characterization of the NKT compartment of a human donor with NKT levels ap..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
The authors acknowledge the following support: S. P. B. is supported by a National Health and Medical Research Council (NHMRC) Career Development Award and an NHMRC Project grant (no. 454363); D. I. G. is supported by an NHMRC Program grant (no. 251608, renewed as no. 454569) and an NHMRC Research Fellowship. L. C. H. is an NHMRC Senior Principal Research Fellow supported by an NHMRC Program grant. We acknowledge the generous assistance of the research team involved in the INIT 2 project at The Burnet Clinical Research Unit and The Walter and Eliza Hall Institute. We also thank 'donor A' and her family for their willingness to participate in this research.