Journal article

Peripheral NKT Cells in Simian Immunodeficiency Virus-Infected Macaques

Caroline S Fernandez, Angela C Chan, Konstantinos Kyparissoudis, Robert De Rose, Dale I Godfrey, Stephen J Kent

JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2009

Abstract

NKT cells are a specialized population of T lymphocytes that have an increasingly recognized role in immunoregulation, including controlling the response to viral infections. The characteristics of NKT cells in the peripheral blood of macaques during simian immunodeficiency virus (SIV) or chimeric simian/human immunodeficiency virus (HIV) (SHIV) infection were assessed. NKT cells comprised a mean of 0.19% of peripheral blood lymphocytes across the 64 uninfected macaques studied. Although the range in the percentages of NKT cells was large (0 to 2.2%), levels were stable over time within individual macaques without SIV/SHIV infection. The majority of NKT cells in macaques were CD4(+) (on aver..

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