The minimal model of glucose disposal in the analysis of glucose effectiveness: Importance of early insulin data

Abstract

Background: Glucose effectiveness (Sg) is an important component in glucose tolerance. Values of Sg using "open loop" glucose kinetic computer programs are usually higher compared to closed loop method (CLM) programs that incorporate insulin secretion modeling. We aimed to test whether these differences are caused by (1) inclusion of insulin secretion modeling or (2) the method of representing plasma insulin values in the first few minutes of the frequently sampled intravenous glucose tolerance test (FSIGT). Methods: FSIGTs without insulin supplementation were performed in six healthy volunteers, and the Bergman minimal model was fitted to the data using the simulation and modeling program S..