Journal article

Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophrenia

Tsutomu Takahashi, Stephen J Wood, Bridget Soulsby, Patrick D McGorry, Ryoichiro Tanino, Michio Suzuki, Dennis Velakoulis, Christos Pantelis

SCHIZOPHRENIA RESEARCH | ELSEVIER SCIENCE BV | Published : 2009

Abstract

Morphologic abnormalities of the insular cortex have been described in psychotic disorders such as schizophrenia, but it remains unknown whether these abnormalities develop progressively over the course of the illness. In the current study, longitudinal magnetic resonance imaging data were obtained from 23 patients with first-episode psychosis (FEP), 11 patients with chronic schizophrenia, and 26 healthy controls. The volumes of the short (anterior) and long (posterior) insular cortices were measured on baseline and follow-up (between 1 and 4 years later) scans and were compared across groups. In cross-sectional comparison at baseline, the FEP and chronic schizophrenia patients had significa..

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