Journal article

Colon epithelial cell differentiation is inhibited by constitutive c-myb expression or mutant APC plus activated RAS

RG Ramsay, D Ciznadija, C Sicurella, N Reyes, K Mitchelhill, PK Darcy, G D'Abaco, T Mantamadiotis

DNA AND CELL BIOLOGY | MARY ANN LIEBERT, INC | Published : 2005

Abstract

Blocked differentiation is a hallmark of cancer cells and the restoration of differentiation programs in vivo is an actively pursued clinical aim. Understanding the key regulators of cyto-differentiation may focus therapies on molecules that reactivate this process. c-myb expression declines rapidly when human colon cancer epithelial cells are induced to differentiate with the physiologically relevant short-chain fatty acid, sodium butyrate. These cells show increased expression of alkaline phosphatase and cytokeratin 8. Similarly, murine Immorto-epithelial cells derived from wild-type colon cells also show c-myb mRNA declines when induced to differentiate with sodium butyrate. Immorto-cells..

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