NMR-determined lipoprotein subclass profile predicts type 2 diabetes

Abstract

Aims: To determine whether nuclear magnetic resonance (NMR)-determined lipoprotein profiles predict type 2 diabetes. Methods: Subjects were 813 male and female participants in the Melbourne Collaborative Cohort Study, aged 40-69 years at baseline (1990-1994), and with a baseline fasting plasma glucose <7.0 mmol/L. Incident type 2 diabetes was identified in 1994-1998 by self-report and confirmation from doctors. Eligible cases and a random group of controls were selected, with NMR data available for 59 cases and 754 non-cases. Results: Concentration of very low density lipoprotein (VLDL) particles (positive) and high density lipoprotein (HDL) particle size (negative) were selected by stepwise..