Journal article
Synchrotron-based angiography for investigation of the regulation of vasomotor function in the microcirculation in vivo
M Shirai, DO Schwenke, GA Eppel, RG Evans, AJ Edgley, H Tsuchimochi, K Umetani, JT Pearson
Clinical and Experimental Pharmacology and Physiology | Published : 2009
Abstract
1. Real-time imaging of the vascular networks of any organ system in vivo is possible with synchrotron radiation (SR) angiography. In this review, we discuss the advantages of SR angiography over clinical X-ray imaging and other non-ionizing imaging modalities. Current limitations are also described. 2. The usefulness of dual-energy and temporal subtraction approaches to K-edge iodine imaging are compared. 3. High-resolution images of the microcirculation in small animals are now being collected routinely by multiple research groups through public access research programmes at synchrotrons worldwide. Such images are permitting unrivalled insights into vasomotor regulation deep within intact ..
View full abstractGrants
Awarded by SPring-8 Program Review Committee
Awarded by Ministry of Education, Culture, Sports, Science and Technology, Japan
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
The synchrotron radiation experiments were performed at the beamline 'BL28B2' in SPring-8 with the approval of the SPring-8 Program Review Committee (Proposal no. 2004B0464-NL2-NP, 2005A0513-NL3-NP, 2005B0525) and the appropriate Animal Ethics committees. The authors' work was supported by a Monash University Synchrotron Fellowship (JTP), Grants-in-Aid for Scientific Research (20590242) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. RGE is a Senior Research Fellow of the National Health and Medical Research Council of Australia (384101). Further, the authors acknowledge financial support from the Access to Major Research Facilities Programme, which is a component of International Science Linkages Programme established under the Australian Government's innovation statement, Backing Australia's Ability.