Journal article

p75 Neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells

Kaylene M Young, Tobias D Merson, Areechun Sotthibundhu, Elizabeth J Coulson, Perry F Bartlett

JOURNAL OF NEUROSCIENCE | SOC NEUROSCIENCE | Published : 2007

Abstract

Although our understanding of adult neurogenesis has increased dramatically over the last decade, confusion still exists regarding both the identity of the stem cell responsible for neuron production and the mechanisms that regulate its activity. Here we show, using flow cytometry, that a small population of cells (0.3%) within the stem cell niche of the rat subventricular zone (SVZ) expresses the p75 neurotrophin receptor (p75(NTR)) and that these cells are responsible for neuron production in both newborn and adult animals. In the adult, the p75(NTR)-positive population contains all of the neurosphere-producing precursor cells, whereas in the newborn many of the precursor cells are p75(NTR..

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University of Melbourne Researchers