Journal article
Development of hydrocephalus in mice lacking SOCS7
DL Krebs, D Metcalf, TD Merson, AK Voss, T Thomas, JG Zhang, S Rakar, MK O'Bryan, TA Willson, EM Viney, LA Mielke, NA Nicola, DJ Hilton, WS Alexander
Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2004
Abstract
SOCS7 is a member of the suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS). SOCS proteins are composed of an N-terminal domain of variable length, a central Src homology 2 domain, and a C-terminal SOCS box. Biochemical and genetic studies have revealed that SOCS1, SOCS2, SOCS3, and CIS play an important role in the termination of cytokine and growth factor signaling. However, the biological actions of other SOCS proteins are less well defined. To investigate the physiological role of SOCS7, we have used gene targeting to generate mice that lack expression of the Socs7 gene. Socs7-/- mice were born in expected numbers, were fertile, and did not exhibit defects i..
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