Natural host genetic resistance to lentiviral CNS sisease: A neuroprotective MHC class I allele in SIV-infected macaques

Abstract

Human immunodeficiency virus (HIV) infection frequently causes neurologic disease even with anti-retroviral treatment. Although associations between MHC class I alleles and acquired immunodeficiency syndrome (AIDS) have been reported, the role MHC class I alleles play in restricting development of HIV-induced organ-specific diseases, including neurologic disease, has not been characterized. This study examined the relationship between expression of the MHC class I allele Mane-A*10 and development of lentiviral-induced central nervous system (CNS) disease using a well-characterized simian immunodeficiency (SIV)/ pigtailed macaque model. The risk of developing CNS disease (SIV encephalitis) wa..