Journal article

Natural Host Genetic Resistance to Lentiviral CNS Disease: A Neuroprotective MHC Class I Allele in SIV-Infected Macaques

Joseph L Mankowski, Suzanne E Queen, Caroline S Fernandez, Patrick M Tarwater, Jami M Karper, Robert J Adams, Stephen J Kent

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2008

Abstract

Human immunodeficiency virus (HIV) infection frequently causes neurologic disease even with anti-retroviral treatment. Although associations between MHC class I alleles and acquired immunodeficiency syndrome (AIDS) have been reported, the role MHC class I alleles play in restricting development of HIV-induced organ-specific diseases, including neurologic disease, has not been characterized. This study examined the relationship between expression of the MHC class I allele Mane-A*10 and development of lentiviral-induced central nervous system (CNS) disease using a well-characterized simian immunodeficiency (SIV)/pigtailed macaque model. The risk of developing CNS disease (SIV encephalitis) was..

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University of Melbourne Researchers

Grants

Awarded by NIH


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

This study was supported by NIH RR019995 (RJA). In addition, animal studies were supported by NIH NS055651, NS047984, NS055648, HL75840, MH69116, and MH070306.