Journal article
Laurencia filiformis: Phytochemical profiling by conventional and HPLC-NMR approaches
DA Dias, JM White, S Urbana
Natural Product Communications | SAGE PUBLICATIONS INC | Published : 2009
Abstract
Chemical investigation of the southern Australian marine alga Laurencia filiformis forma heteroclada resulted in the isolation of two new compounds, cycloisoallolaurinterol (16) and isoallolaurinterol (23), along with the previously reported sesquiterpenes filiformin (1), filiforminol (2), allolaurinterol (3) and bromolaurenisol (10). All structures were secured by detailed spectroscopic analysis since no previous 2D NMR studies had been described for compounds 1, 2 and 10. As a result of this study, the first single X-ray diffraction study for 1 was secured. The investigation of the chemical conversion of allolaurinterol (3) to filiformin (1) was monitored by on-flow HPLC-NMR, which also re..
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Funding Acknowledgements
The Marine And Terrestrial Natural Product (MATNAP) Research Group thanks Dr G. Kraft (University of Melbourne, Victoria, Australia) for the marine algal identification; Ms Gill Ellis (University of Canterbury, Christchurch, New Zealand) for the biological testing; Ms Sally Duck (School of Chemistry, Faculty of Science, Monash University) for high resolution mass spectrometry analysis; Dr Sylvia Urban and Dr Rick Tinker for the collection of the alga; Ms Angela You for preliminary fractionations of the alga; the award of an Australian Postgraduate Award (APA) scholarship.