Journal article

Invasion by P-falciparum merozoites suggests a hierarchy of molecular interactions

Jake Baum, Alexander G Maier, Robert T Good, Ken M Simpson, Alan F Cowman

PLOS PATHOGENS | PUBLIC LIBRARY SCIENCE | Published : 2005

Abstract

Central to the pathology of malaria disease are the repeated cycles of parasite invasion and destruction of human erythrocytes. In Plasmodium falciparum, the most virulent species causing malaria, erythrocyte invasion involves several specific receptor-ligand interactions that direct the pathway used to invade the host cell, with parasites varying in their dependency on these different pathways. Gene disruption of a key invasion ligand in the 3D7 parasite strain, the P. falciparum reticulocyte binding-like homolog 2b (PfRh2b), resulted in the parasite invading via a novel pathway. Here, we show results that suggest the molecular basis for this novel pathway is not due to a molecular switch b..

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University of Melbourne Researchers