Impact of steroid hormone signals on Drosophila cell cycle during development
Nicola Cranna, Leonie Quinn
CELL DIVISION | BIOMED CENTRAL LTD | Published : 2009
Metamorphosis of Drosophila involves proliferation, differentiation and death of larval tissues in order to form the adult fly. The major steroid hormone implicated in the larval-pupal transition and adult tissue modelling is ecdysone. Previous reviews have draw together studies connecting ecdysone signaling to the processes of apoptosis and differentiation. Here we discuss those reports connecting the ecdysone pulse to developmentally regulated cell cycle progression.
We thank Helena Richardson for critical reading of the manuscript. We thank Bloomington stock centre for Drosophila strains. We thank Ben Britten Smith for image analysis software. This work was supported by grants from the Australian National Health and Medical Research Council (NHMRC) and The Cancer Council of Victoria (CCV). LQ is an NHMRC RD Wright Research Fellow.