Journal article

Localisation and Expression of FoxO1 Proteins in Human Gestational Tissues

M Lappas, R Lim, C Riley, GE Rice, M Permezel

PLACENTA | W B SAUNDERS CO LTD | Published : 2009

Abstract

In non-gestational tissues, emerging data indicate that the FoxO1 family of Forkhead transcription factors play diverse roles in many cellular processes coordinating programs of gene expression that regulate apoptosis, oxidative stress resistance, and immune cell homeostasis. Successful outcome of human parturition rely on many of these processes, however there is no data available on FoxO1 proteins in human intrauterine tissues, nor their role in pregnancy complications such as pre-eclampsia. Thus the aim of this study was (i) to characterises the localisation and expression of FoxO1, acetylated (ac)-FoxO1 and phosphorylated (p)-FoxO1 in human placenta and fetal membranes obtained from term..

View full abstract

Grants

Awarded by National Health and Medical Research Council RD Wright Fellowship


Awarded by NHMRC


Funding Acknowledgements

Dr Martha Lappas is in recipient of a National Health and Medical Research Council RD Wright Fellowship (grant no. 454777), The work described in this manuscript was funded in part by a NHMRC Project grant (grant no. 367615) and by the Trevor Basil Kilvington Bequest. Funding for the Chemi-Doc system was provided by the Medical Research Foundation for Women and Babies. The authors gratefully acknowledge the assistance of the Clinical Research Midwives Gabrielle Fleming, Astrid Tiefholz, Anne Beeston and Renee Grant, and the Obstetrics and Midwifery staff of the Mercy Hospital for Women for their co-operation.