Journal article

Connectivity of the human periventricular-periaqueductal gray region

E Sillery, RG Bittar, MD Robson, TEJ Behrens, J Stein, TZ Aziz, H Johansen-Berg

JOURNAL OF NEUROSURGERY | AMER ASSOC NEUROLOGICAL SURGEONS | Published : 2005

Abstract

OBJECT: The periventricular gray (PVG) zone and its continuation, the periaqueductal gray (PAG) substance, have been targets for deep brain stimulation (DBS) in the alleviation of intractable pain for longer than two decades. Nevertheless, the anatomical connectivity of this region has been fairly poorly defined. The effects of DBS in this region are probably related to the release of endogenous endorphins, but until the connectivity of this region is better understood the mechanisms will remain unclear. METHODS: Diffusion tractography was used to trace the pathways of the PVG-PAG region in seven healthy human volunteers. Images were acquired with the aid of a 1.5-tesla magnetic resonance im..

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