Journal article

Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage

SM Davis, J Broderick, M Hennerici, NC Brun, MN Diringer, SA Mayer, K Begtrup, T Steiner

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2006


BACKGROUND: Although volume of intracerebral hemorrhage (ICH) is a predictor of mortality, it is unknown whether subsequent hematoma growth further increases the risk of death or poor functional outcome. METHODS: To determine if hematoma growth independently predicts poor outcome, the authors performed an individual meta-analysis of patients with spontaneous ICH who had CT within 3 hours of onset and 24-hour follow-up. Placebo patients were pooled from three trials investigating dosing, safety, and efficacy of rFVIIa (n = 115), and 103 patients from the Cincinnati study (total 218). Other baseline factors included age, gender, blood glucose, blood pressure, Glasgow Coma Score (GCS), intraven..

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