Journal article
Discharge patterns of human genioglossus motor units during arousal from sleep
V Wilkinson, A Malhotra, CL Nicholas, C Worsnop, AS Jordan, JE Butler, JP Saboisky, SC Gandevia, DP White, J Trinder
Sleep | Published : 2010
Abstract
Study Objectives: Single motor unit recordings of the human genioglossus muscle reveal motor units with a variety of discharge patterns. Integrated multiunit electromyographic recordings of genioglossus have demonstrated an abrupt increase in the muscle's activity at arousal from sleep. The aim of the present study was to determine the effect of arousal from sleep on the activity of individual motor units as a function of their particular discharge pattern. Design: Genioglossus activity was measured using intramuscular fine-wire electrodes inserted via a percutaneous approach. Arousals from sleep were identified using the ASDA criterion and the genioglossus electromyogram recordings analyzed..
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Awarded by National Health and Medical Research Council, Australia
Funding Acknowledgements
This work was performed at the Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School and the Department of Psychology, University of Melbourne. Financial support for this study came from the National Health and Medical Research Council, Australia. Project Grant 454458. No off-label or investigational drugs were used.