Journal article

Bone mass effects of a BMP4 gene polymorphism in postmenopausal women

LR Babu, SG Wilson, IM Dick, FMA Islam, A Devine, RL Prince

BONE | ELSEVIER SCIENCE INC | Published : 2005

Abstract

The pathogenesis of osteoporosis involves both genetic and environmental factors. On the basis of linkage data suggesting gene effects on bone density at chromosome 14q and data locating the BMP4 gene to 14q, we performed a positional candidate study to examine a possible association of BMP4 gene polymorphisms, hip bone density (n = 1012) and fracture rates (n = 1232) in postmenopausal women (mean age 75). On genotype analysis of the three selected single nucleotide polymorphisms (SNP), the 6007C > T polymorphism was associated with total and intertrochanteric hip BMD and BMD was lower in the 32% of subjects homozygous for the C allele. This polymorphism codes for a nonsynonymous amino acid ..

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