Bone mineral density and its determinants in diabetes: the Fremantle Diabetes Study

Abstract

AIMS/HYPOTHESIS: We assessed the effects of type 1 and type 2 diabetes on bone density and metabolism. MATERIALS AND METHODS: We analysed bone mineral density (BMD) measured at the hip, spine and forearm using dual energy X-ray absorptiometry in 34 patients with type 1 and 194 patients with type 2 diabetes. Patients were from the community-based Fremantle Diabetes Study, and findings for them were compared with those from normal age- and sex-matched control subjects from the local community. Biochemical and hormonal markers of bone metabolism were measured in a subset of 70 patients. RESULTS: After adjusting for age and BMI, there was a lower BMD at total hip (p<0.001) and femoral neck (p=0...