Dopamine and the Dopamine Oxidation Product 5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of alpha-Synuclein in a pH-Dependent Manner

Chi LL Pham; Su Ling Leong; Feda E Ali; Vijaya B Kenche; Andrew F Hill; Sally L Gras; Kevin J Barnham; Roberto Cappai

Journal article

Dopamine and the Dopamine Oxidation Product 5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of alpha-Synuclein in a pH-Dependent Manner

Chi LL Pham, Su Ling Leong, Feda E Ali, Vijaya B Kenche, Andrew F Hill, Sally L Gras, Kevin J Barnham, Roberto Cappai

Journal of Molecular Biology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2009

DOI: 10.1016/j.jmb.2009.02.007

University of Melbourne Researchers

Kevin Barnham Author Florey Department of Neuroscience and Mental Health

Roberto Cappai Author Pharmacology and Therapeutics

Sally Gras Author Chemical Engineering

Vijaya Kenche Author Clinical Pathology

Grants

Funding Acknowledgements

This work was Supported by the National Health and Medical Research Council of Australia and the NeUroproteomics and Neurogenomics Facility at The University of Melbourne. S.L.L. is the recipient of an Australian Postgraduate Award. R.C., K.J.B,. and A.F.H. are National Health and Medical Research COL11-161 of Australia Research Fellows.