Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis
Scott Kolbe, Caron Chapman, Thanh Nguyen, Clare Bajraszewski, Leigh Johnston, Michael Kean, Peter Mitchell, Mark Paine, Helmut Butzkueven, Trevor Kilpatrick, Gary Egan
Neuroimage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2009
Recently, there has been strong interest in the development of imaging techniques to quantify axonal and myelin pathology in patients with multiple sclerosis (MS). Optic neuritis, a condition characterised by inflammatory demyelination of the optic nerve, is one of the commonest sites of MS relapse, and exhibits similar pathological alterations to MS lesions elsewhere in the central nervous system (CNS). Unlike other regions of the CNS, however, the function of the optic nerve can be accurately assessed using clinical measures, as well as electrophysiological techniques such as visual evoked potential recordings. Therefore, optic neuritis is useful for investigating the relationship between ..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
Awarded by MS Research Australia/Trish MS Foundation/NHMRC Betty Cuthbert Fellowship
This work was supported by the National Health and Medical Research Council (NHMRC) Principal Research Fellowship (Grant 400317, G. F. Egan), Australia; the joint MS Research Australia/Trish MS Foundation/NHMRC Betty Cuthbert Fellowship (Grant 400476, H. Butzkueven); the joint MS Research Australia/Australian Financial Advisors Association Postgraduate Scholarship (S. Kolbe); Charity-works for MS, Melbourne; and the Neurosciences Victoria Neuro-Informatics Platform. We thank all the participants in our study, Dr Michael Ditchfield at the Murdoch Children's Research Institute MRI facility, and Dr Alexander Klistorner for invaluable advice and use of software for multifocal VEP analysis.