Morphometric abnormalities and hyperanxiety in genetically epileptic rats: A model of psychiatric comorbidity?
Viviane Bouilleret, R Edward Hogan, Dennis Velakoulis, Michael R Salzberg, Lei Wang, Gary F Egan, Terence J O'Brien, Nigel C Jones
NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2009
BACKGROUND: Imaging studies of epilepsy patients with comorbid affective disturbance demonstrate morphometric changes in limbic brain regions implicated in psychiatric disease. Genetic Absence Epilepsy Rats from Strasbourg (GAERS), specifically bred for their epilepsy phenotype, also exhibit elevated anxiety-like behaviors suggesting a common causality. Here we examined whether relevant cerebral morphological alterations exist in this rat strain using volumetric measurements and large deformation high dimensional mapping (HDM-LD), a tool recently validated to produce accurate three-dimensional surface representations of the hippocampus. METHODS: Volumetric MRI and the Open Field test of anxi..View full abstract
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Awarded by NHMRC
This research was supported by an NHMRC project grant (# 400088) to TJO and MS and a Special Purposes Grant from the University of Melbourne to NJ.Financial disclosureThe authors declare no conflicts financial or otherwise, associated with this work.