Journal article

Dietary phytoestrogens dampen female sexual behavior in mice with a disrupted aromatase enzyme gene

Andrea E Kudwa, Wah C Boon, Evan R Simpson, Robert J Handa, Emilie F Rissman

BEHAVIORAL NEUROSCIENCE | AMER PSYCHOLOGICAL ASSOC | Published : 2007

Abstract

Aromatization of testosterone (T) to estradiol (E2) during perinatal development in male rodents plays a significant role in sexual differentiation of the brain and adult behaviors. Exposure to estrogens during development can enhance masculine behaviors in adult females and reduce expression of female-typical behaviors in adult males. Previous studies have shown that, in addition to naturally occurring estrogens, dietary phytoestrogens can affect sexual differentiation. To distinguish between the effects of endogenous T-derived E2 and exogenous phytoestrogens, the authors used an aromatase knockout (ArKO) mouse that cannot produce E2 but is responsive to E2 via estrogen receptors alpha and ..

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University of Melbourne Researchers