Estrogen deficiency results in apoptosis in the frontal cortex of adult female aromatase knockout mice
Rachel A Hill, Hui Kheng Chua, Margaret EE Jones, Evan R Simpson, Wah Chin Boon
MOLECULAR AND CELLULAR NEUROSCIENCE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2009
The aromatase knockout (ArKO) mouse is completely estrogen deficient. We previously detected apoptosis in the hypothalamus of 1 year-old male ArKO mice. This study shows that 12 week-old female ArKO mice display spontaneous apoptosis of pyramidal neurons in the frontal cortex while wild-type (WT) littermates show no signs of apoptosis. Concomitantly, bcl-2 related anti-apoptotic genes are down-regulated whereas the pro-apoptotic gene TRADD is up-regulated in the female ArKO frontal cortex. This phenotype can be rescued by 3-week replacement of 17beta-estradiol. Furthermore, the apoptosis phenotype is exacerbated in 12-15 month-old female ArKO mice, which have 30% less neurons in the frontal ..View full abstract
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Awarded by Australian National Health and Medical Research Council
This work was Supported by the Australian National Health and Medical Research Council, project grant numbers 338510 and 494813.