Journal article

Transience of MHC Class I-restricted antigen presentation after influenza A virus infection

Justine D Mintern, Sammy Bedoui, Gayle M Davey, Jessica M Moffat, Peter C Doherty, Stephen J Turner

Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2009

Abstract

Antigen expressed as MHC Class I glycoprotein (pMHCI) complexes on dendritic cells is the primary driver of CD8(+) T cell clonal expansion and differentiation. As we seek to define the molecular differences between acutely stimulated cytotoxic T lymphocyte (CTL) effectors and long-lived memory T cells, it is essential that we understand the duration of in vivo pMHCI persistence. Although infectious influenza A virus is readily cleared by mammalian hosts, that does not necessarily mean that all influenza antigen is totally eliminated. An exhaustive series of carefully controlled adoptive transfer experiments using 3 different carboxy fluorescein diacetate succinimidyl ester-labeled T cell rec..

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Grants

Awarded by Australian National Health and Medical Research


Awarded by National Health and Medical Research Council Program


Awarded by National Institutes of Health


Funding Acknowledgements

We thank Drs. Nicole La Gruta and Katherine Kedzierska for helpful discussion. J.D.M. was supported by Australian National Health and Medical Research Project Grant 508905 and The University of Melbourne C. R. Roper Fellowship. P.C.D. was supported by National Health and Medical Research Council Program Grant 299907 and National Institutes of Health Grant AI170251. S.J.T. was supported by a Pfizer Senior Research Fellowship.