Treatment switches after viral rebound in HIV-infected adults starting antiretroviral therapy: Multicentre cohort study: The United Kingdom Collaborative HIV Cohort (CHIC) Study

Abstract

Objective: To describe the time from first viral rebound on highly active antiretroviral therapy to first treatment change, identify factors associated with more rapid switching, and investigate whether treatment changes are in line with treatment guidelines. Design and setting: A multicentre cohort study. Methods: We described the time to first treatment switch among individuals experiencing confirmed virological rebound after initiating highly active antiretroviral therapy; factors associated with more rapid switching were identified using proportional hazards regression and predictors of a switch in line with guidelines were identified using logistic regression. Results: Thirty-four perce..