Journal article

Neuropeptide Y receptor-specifically modulates human neutrophil function

Sammy Bedoui, Andreas Kromer, Thomas Gebhardt, Roland Jacobs, Kerstin Raber, Mirja Dimitrijevic, Joern Heine, Stephan von Hoersten

JOURNAL OF NEUROIMMUNOLOGY | ELSEVIER SCIENCE BV | Published : 2008

Abstract

Despite a continuously growing body of evidence highlighting the role of NPY in the immune system, surprisingly little is known about its ability to alter human leukocyte function. We therefore set out to examine NPY receptor expression and functional effects of NPY in freshly isolated human neutrophils. Our results not only demonstrate for the first time the presence of specific NPY receptors on human neutrophils, but also unveil of how these receptors differentially modulate critical functions of neutrophils such as phagocytosis of bacteria as well as the release of reactive oxygen species.