Journal article

Relationship between body adiposity measures and risk of primary knee and hip replacement for osteoarthritis: a prospective cohort study

Yuanyuan Wang, Julie Anne Simpson, Anita Wluka, Andrew J Teichtahl, Dallas R English, Graham G Giles, Stephen Graves, Flavia M Cicuttini



INTRODUCTION: Total joint replacement is considered a surrogate measure for symptomatic end-stage osteoarthritis. It is unknown whether the adipose mass and the distribution of adipose mass are associated with the risk of primary knee and hip replacement for osteoarthritis. The aim of the present investigation was to examine this in a cohort study. METHODS: A total of 39,023 healthy volunteers from Melbourne, Australia were recruited for a prospective cohort study during 1990 to 1994. Their body mass index, waist circumference, and waist-to-hip ratio were obtained from direct anthropometric measurements. The fat mass and percentage fat were estimated from bioelectrical impedance analysis. Pr..

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Awarded by National Health and Medical Research Council

Awarded by NHMRC Public Health (Australia) Fellowships

Funding Acknowledgements

The MCCS recruitment was funded by VicHealth and The Cancer Council of Victoria. The MCCS was funded by a program grant from the National Health and Medical Research Council (NHMRC 209057), a capacity-building grant (NHMRC 251533), and an enabling grant (NHMRC 396414), and was further supported by infrastructure provided by The Cancer Council of Victoria. YW and AEW are the recipients of NHMRC Public Health (Australia) Fellowships (NHMRC 465142 and NHMRC 317840, respectively). The authors would especially like to thank data manager Lisa Ingerson and statistician Nicole Pratt from the Australian Orthopaedic Association National Joint Replacement Registry, and Ms Georgina Marr from The Cancer Council Victoria.