Obesity and adiposity are associated with the rate of patella cartilage volume loss over 2 years in adults without knee osteoarthritis
AJ Teichtahl, Anita Wluka, Y Wang, F Hanna, DR English, GG Giles, Flavia M Cicuttini
ANNALS OF THE RHEUMATIC DISEASES | BMJ PUBLISHING GROUP | Published : 2009
OBJECTIVES: The aim of this study was to determine whether measures of obesity and adiposity are associated with the rate of patella cartilage volume loss in healthy adults. METHODS: 297 community-based adults aged 50-79 years with no clinical knee osteoarthritis were recruited at baseline (2003-4). 271 (62% female) subjects were re-examined at follow-up (2006-7). Measures of obesity (body mass index (BMI) and weight) and adiposity (fat mass and percentage fat mass), as well as patella cartilage volume, were determined by established protocols. RESULTS: Patella cartilage volume was lost at an annual rate of 1.8% (95% CI 1.4% to 2.1%). Increased baseline BMI, weight, fat mass and percentage f..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by NHMRC Public Health ( Australia)
The Melbourne Collaborative Cohort Study recruitment was funded by VicHealth and The Cancer Council Victoria. This study was funded by a programme grant ( 209057) and enabling grant ( 396414) from the National Health and Medical Research Council and was further supported by infrastructure provided by the Cancer Council Victoria. YW and AEW are the recipients of NHMRC Public Health ( Australia) fellowships ( NHMRC 465142 and 317840, respectively).