Journal article

Effect of latanoprost on intraocular pressure in mice lacking the prostaglandin FP receptor

JG Crowston, JD Lindsey, M Aihara, RN Weinreb

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2004

Abstract

PURPOSE: To determine whether latanoprost lowers IOP in prostaglandin FP receptor knockout mice. METHODS: Mean IOP difference between treated and untreated fellow eyes was measured on three separate occasions, 2 hours after a 200-ng dose of latanoprost to the right eye of homozygous (n = 9) and heterozygous (n = 15) FP knockout mice. C57BL/6 (n = 10) and NIH Swiss white mice (n = 17), which have normal FP receptor expression, provided the control population. The investigator was masked to the genotype of the FP knockout mice at the time of IOP measurement. RESULTS: Latanoprost had no effect on IOP in the homozygous FP knockout mice, with an average difference in IOP between treated and untre..

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