Journal article
Fine mapping linkage analysis identifies a novel susceptibility locus for myopia on chromosome 2q37 adjacent to but not overlapping MYP12
M Schäche, CY Chen, KK Pertile, AJ Richardson, M Dirani, P Mitchell, PN Baird
Molecular Vision | Published : 2009
Abstract
Purpose: Myopia (shortsightedness) is one of the most common ocular conditions worldwide and results in blurred distance vision. It is a complex trait influenced by both genetic and environmental factors. We have previously reported linkage of myopia to a 13.01 cM region of chromosome 2q37 in three large multigenerational Australian families that initially overlapped with the known myopia locus, MYP12. The purpose of this study was to perform fine mapping of this region and identify single nucleotide polymorphisms (SNPs) associated with myopia. Methods: Fine mapping linkage analysis was performed on three multigenerational families with common myopia to refine the previously mapped critical ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors wish to thank participants from the GEM, BMES, and VIP studies who made this work possible. This work was supported by the Australian Federal Government through the Cooperative Research Centres Program, the Joan and Peter Clemenger Trust, the Angior Family Foundation, the Myra Stoicescu Trust, the William Buckland Foundation, the Eye Research Australia Foundation, the Sunshine Foundation, the Helen Macpherson Smith Trust, the National Health and Medical Research Council (grant number 529912), and the L. E. W. Carty Trust. The authors wish to state that there are no conflicts of interest.