Relation of Age-related Cataract With Obesity and Obesity Genes in an Asian Population
Laurence S Lim, E-Shyong Tai, Tin Aung, Wan Ting Tay, Seang Mei Saw, Mark Seielstad, Tien Yin Wong
AMERICAN JOURNAL OF EPIDEMIOLOGY | OXFORD UNIV PRESS INC | Published : 2009
Obesity shows an inconsistent association with cataract. Causality has not been established. Polymorphisms at the fat mass- and obesity-associated (FTO) locus are associated with obesity and offer an opportunity to examine the obesity-cataract association using a mendelian randomization approach. The authors conducted a population-based study among Singaporean Malay adults (2004-2006) in which nuclear, cortical, and posterior subcapsular (PSC) cataracts were assessed and defined by slit-lamp examination using Lens Opacity Classification System III. Obesity was defined as body mass index (weight (kg)/height (m)(2)) > or =30. The study included 3,000 subjects, of whom 1,339 (44.6%) had catarac..View full abstract
Awarded by Singapore National Medical Research Council
Awarded by Singapore Biomedica lResearch Council
This study was supported by Singapore National Medical Research Council grants 0796/2003, 0863/2004, and CSI/0002/2005 and Singapore Biomedica lResearch Council grant 501/1/25-5, with additional support from the Singapore Tissue Network, the Singapore Ministry of Health, and the Genome Institute of Singapore (for genotyping costs).